Hydrochloric Acid → FK1052 hydrochloride

HRID 486189ノート

反応式

HRID 486189 の反応式
[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]2[C:11](=[O:22])[CH:12]([CH2:15][C:16]3[N:17]=[CH:18][NH:19][C:20]=3[CH3:21])[CH2:13][CH2:14][C:3]=12.[ClH:23]>CO.C(O)C>[ClH:23].[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]2[C:11](=[O:22])[CH:12]([CH2:15][C:16]3[N:17]=[CH:18][NH:19][C:20]=3[CH3:21])[CH2:13][CH2:14][C:3]=12

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 125368FK 1052

生成物 1

HCID 9949384FK1052 hydrochloride

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒2 回HCID 887Methanol溶媒

実験手順

The suspension of 8,9-dihydro-10-methyl-7-[(5-methyl-1H-imidazol-4-yl)methyl]pyrido[1,2-a]indol-6(7H)-one (2.0 g) in methanol (60 ml) was treated with hydrogen chloride in ethanol and then diluted with hot aqueous ethanol (water:ethanol, 1:4) to give a clear solution. After filtration of the insoluble materials, the filtrate was evaporated under reduced pressure to about 40 ml and allowed to stand at room temperature overnight. Filtration, followed by washing with ethanol, gave 8,9-dihydro-10-methyl-7-[(5-methyl-1H-imidazol-4-yl)methyl]pyrido[1,2-a]indol-6(7H)-one hydrochloride (2.10 g) as crystals.

後処理

  1. customto give a clear solution
  2. filtrationAfter filtration of the insoluble materials
  3. customthe filtrate was evaporated under reduced pressure to about 40 ml
  4. filtrationFiltration
  5. washby washing with ethanol

出典と根拠

ORDレコード
ord-ce7ea70b3a9840f984da19c53a88fc39
出典データセット
uspto-grants-1994_03
特許番号
US05290785

反応ノート

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