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2-Methylthiomethyl-3,4,6-trifluoroaniline → 3,4,6-Trifluoro-2-methylaniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Methylthiomethyl-3,4,6-trifluoroaniline | HCID 18974461 | — |
| 触媒 | Nickel | HCID 935 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3,4,6-Trifluoro-2-methylaniline | HCID 22625178 | 71.3% |
反応手順
To 2-methylthiomethyl-3,4,6-trifluoroaniline (22.2 g) are added ethanol (400 ml) and Raney nickel (200 g) and the mixture is stirred at room temperature for 30 minutes. After the catalyst is filtered off, the filtrate is added with water and extracted with dichloromethane. The is dried over magnesium sulfate and concentrated to give 2-methyl-3,4,6-trifluoroaniline (12.3 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05290934 |
| 出典データセット | uspto-grants-1994_03 |
| ORD ID | ord-65a42f8c16c84334b479a3ff0c9274d7 |
| 出典メモ | uspto-grants-1994_03 |