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Ammonium Chloride → 4-(4-n-Propylphenyl)trifluorotoluene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | Benzene, 1-bromo-4-(trifluoromethyl)- | HCID 67872 | — |
| 反応物 | 1-Bromo-4-propylbenzene | HCID 136374 | — |
| 反応物 | Magnesium | HCID 5462224 | — |
| 触媒 | Zinc bromide | HCID 10421208 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-(4-n-Propylphenyl)trifluorotoluene | HCID 14985193 | — |
反応手順
11.2 g of anhydrous zinc bromide in 25 ml of THF are added dropwise at about 0° to a Grignard solution prepared from 20 g of 4-n-propylbromobenzene and 2.4 g of magnesium turnings in 100 ml of THF. After the mixture has been stirred for 2 hours, a mixture of 22.5 g of 4-bromotrifluorotoluene, 1.5 g of [(diphenylphosphine)ferrocenyl]palladium(II) chloride and 25 ml of THF is added dropwise, and the mixture is stirred for 24 hours at room temperature and poured into 100 ml of saturated ammonium chloride solution. Customary work-up gives 4-(4-n-propylphenyl)trifluorotoluene, M.p. 97° C., Δε=14.2, viscosity η (20° C.)=6 mm2 /s.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05292454 |
| 出典データセット | uspto-grants-1994_03 |
| ORD ID | ord-9a287455070b4912bc1db937bf0676e8 |
| 出典メモ | uspto-grants-1994_03 |