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Sulfuric Acid → 1-(2,4,6-Trimethylphenyl)piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | Ammonium Hydroxide | HCID 14923 | — |
| 反応物 | 1-Mesityl-4-[(4-methylphenyl)sulfonyl]piperazine | HCID 16645603 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 1-(2,4,6-Trimethylphenyl)piperazine | HCID 2760822 | 69% |
反応手順
To a stirred mixture of 180 parts of 1-[(4-methylphenyl)sulfonyl]-4-(2,4,6-trimethylphenyl)piperazine and 450 parts of water were added dropwise 675 parts of sulfuric acid. The whole was stirred and refluxed for 4 hours. After cooling, the whole was treated with an ammonium hydroxide solution. The product was extracted with dichloromethane. The extract was dried, filtered and evaporated, yielding 70 parts (69%) of 1-(2,4,6-trimethylphenyl)piperazine as a residue (intermediate 14).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05292738 |
| 出典データセット | uspto-grants-1994_03 |
| ORD ID | ord-9c3e9e9c6f994e3997e6d57254668174 |
| 出典メモ | uspto-grants-1994_03 |