Acetic Anhydride → N-(3,5-Dimethylphenyl)acetamide
反応式
[CH3:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([CH3:9])[CH:8]=1)[NH2:5].[C:10](OC(=O)C)(=[O:12])[CH3:11]>C1(C)C=CC=CC=1>[C:10]([NH:5][C:4]1[CH:6]=[C:7]([CH3:9])[CH:8]=[C:2]([CH3:1])[CH:3]=1)(=[O:12])[CH3:11]参加物
4
実験手順
To a solution of 15.2 g (125 mmole) of 3,5-dimethylaniline in 60 mL of toluene was added 15 g (146 mmole) of acetic anhydride, whereupon the internal temperature rose to 75° C. The mixture was allowed to cool to room temperature and the solvent was removed in vacuo. The residue was dissolved in 150 mL of hot ethyl acetate and the solution allowed to stand for 16 hours. The resulting mixture was cooled at 5° C. for 3 hours and the solid collected by filtration to give 18.43 g (90%) of off white crystals.
後処理
- customrose to 75° C
- customthe solvent was removed in vacuo
- dissolutionThe residue was dissolved in 150 mL of hot ethyl acetate
- temperatureThe resulting mixture was cooled at 5° C. for 3 hours
- filtrationthe solid collected by filtration
- customto give 18.43 g (90%) of off white crystals
出典と根拠
- ORDレコード
- ord-e389885e93f5457a942f29481ccb18b6
- 出典データセット
- uspto-grants-1994_03
- 特許番号
- US05292726
反応ノート
読み込み中…