Methylamine → Methyl (E)-4-{4-((1-methylamino-2-nitroethen-1-yl)amino)phenyl}-3-butenoate
反応式
CS[C:3]([NH:8][C:9]1[CH:14]=[CH:13][C:12](/[CH:15]=[CH:16]/[CH2:17][C:18]([O:20][CH3:21])=[O:19])=[CH:11][CH:10]=1)=[CH:4][N+:5]([O-:7])=[O:6].[CH3:22][NH2:23]>CO>[CH3:22][NH:23][C:3]([NH:8][C:9]1[CH:14]=[CH:13][C:12](/[CH:15]=[CH:16]/[CH2:17][C:18]([O:20][CH3:21])=[O:19])=[CH:11][CH:10]=1)=[CH:4][N+:5]([O-:7])=[O:6]参加物
4
実験手順
1.00 g of methyl (E)-4-{4-((1-methylthio-2-nitroethen-1-yl)amino)phenyl}-3-butenoate was suspended in 5 ml of methanol, followed by the addition of 1.25 ml of a 40% solution of methylamine in methanol. The obtained mixture was stirred at a room temperature for 4 hours and distilled to remove the solvent. The residue was purified by silica gel column chromatography [solvent: dichloromethane/methanol (30:1)] to obtain 0.5 g of the title compound as a pale yellow solid (yield: 54%).