HCID 19096630、化合物 → HCID 12711612、化合物

HRID 486853ノート

反応式

HRID 486853 の反応式
[Cl:1][CH2:2][C:3]1[O:8][C:7](=[O:9])[CH2:6][CH2:5][CH:4]=1>[C].[Pd].C(OCC)(=O)C>[Cl:1][CH2:2][CH:3]1[O:8][C:7](=[O:9])[CH2:6][CH2:5][CH2:4]1

参加物

4

反応物 1

HCID 19096630HCID 19096630、化合物

生成物 1

HCID 12711612HCID 12711612、化合物収率 96%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 8857Ethyl Acetate溶媒2 回

実験手順

A mixture of 150 mg (1.024 mmol) of (-)-6-chloromethyldihydropyran-2-one obtained in Example 4, 6 ml of ethyl acetate and 60 mg of 10% palladium-carbon was stirred for 2 hours under hydrogen atmosphere. After completion of the reaction, the catalyst was removed by filtration, and the solvent was distilled off. Afterward, the resultant residue was subjected to column chromatography (an eluent of hexane:ethyl acetate=5:1), thereby obtaining 146 mg (yield 96%) of (-)-6-chloromethyltetrahydropyran-2-one having

後処理

  1. customAfter completion of the reaction
  2. customthe catalyst was removed by filtration
  3. distillationthe solvent was distilled off

出典と根拠

ORDレコード
ord-e7c9c0401dd84bdc93bb8e680c2a9deb
出典データセット
uspto-grants-1994_03
特許番号
US05292891

反応ノート

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