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Ammonium Hydroxide → 4-Quinolinamine, 8-fluoro-N-[2-(2-naphthalenyl)ethyl]-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonium Hydroxide | HCID 14923 | — |
| 反応物 | 4-Chloro-8-fluoroquinoline | HCID 2736587 | — |
| 反応物 | 2-(2-Naphthyl)ethyl-amine | HCID 3784378 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-Quinolinamine, 8-fluoro-N-[2-(2-naphthalenyl)ethyl]- | HCID 164182 | 41.2% |
反応手順
A mixture of 2.0 g of 4-chloro-8-fluoroquinoline and 3.8 g of 2-(2-naphthyl)ethyl amine was heated under nitrogen to 160°-165° C. for one hour. Then 200 mL of a 50:50 mixture of ammonium hydroxide in water was added. The product was extracted from the mixture into CH2Cl2, which was then concentrated to dryness. The residue was recrystallized from pentane/ethyl acetate to give 1.4 g of the title product. Yield 41.2%. M.P. 173°-174° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05294622 |
| 出典データセット | uspto-grants-1994_03 |
| ORD ID | ord-d8b4fa2d8fff4f86a05204c132ef765e |
| 出典メモ | uspto-grants-1994_03 |