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Triethylamine → N-(3,5-di-t-butyl-4-hydroxycinnamyl)serine methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 3-(3,5-Ditert-butyl-4-hydroxyphenyl)prop-2-enoic acid | HCID 99819 | — |
| 反応物 | L-Serine, methyl ester, hydrochloride (1:1) | HCID 2723730 | — |
| 反応物 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-(3,5-di-t-butyl-4-hydroxycinnamyl)serine methyl ester | HCID 54523948 | 35.5% |
反応手順
First, 20 g of 3,5-di-t-butyl-4-hydroxycinnamic acid, 11.2 g of serine methyl ester hydrochloride, 13.6 g of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride, and 10 ml of triethylamine were added to 300 ml of dichloromethane, and then the mixture was allowed to react for 2 hours at room temperature. After completion of the reaction, this mixture was washed by addition of water, and the dichloromethane was distilled off under reduced pressure. The residue so obtained was separated and purified by column chromatography on silica gel using chloroform as an eluent, thereby obtaining 9.3 g of N-(3,5-di-t-butyl-4-hydroxycinnamyl)serine methyl ester.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05294624 |
| 出典データセット | uspto-grants-1994_03 |
| ORD ID | ord-1f9588546adb4655b185b9de17e9d700 |
| 出典メモ | uspto-grants-1994_03 |