化工社化工社 化学情報印刷レポート · 研究参考用
tert-Butyldimethylsilyl chloride → (-)-(1R,2S)-2-phenyl-1-cyclohexyl triisopropylsilyloxyacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| 反応物 | Triisopropylsilyl chloride | HCID 139400 | — |
| 反応物 | (-)-(1R,2S)-2-phenyl-1-cyclohexyl hydroxyacetate | HCID 10059921 | — |
| 反応物 | 5-Methyl-2-(propan-2-yl)cyclohexyl 2-hydroxyacetate | HCID 16770157 | — |
| 反応物 | (+)-(1S,2R)-2-phenyl-1-cyclohexyl hydroxyacetate | HCID 67834441 | — |
| 生成物 | (-)-(1R,2S)-2-phenyl-1-cyclohexyl triisopropylsilyloxyacetate | HCID 10000489 | — |
反応手順
In the same manner, 1a, 1b, and 1c(+) were prepared from the combinations of (-)-menthyl hydroxyacetate with tertbutyldimethylsilyl chloride, (-)-(1R,2S)-2-phenyl-1-cyclohexyl hydroxyacetate with tert-butyldimethylsilyl chloride, and (+)-(1S,2R)-2-phenyl-1-cyclohexyl hydroxyacetate with triisopropylsilyl chloride, respectively, in 90-95% yields.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05294737 |
| 出典データセット | uspto-grants-1994_03 |
| ORD ID | ord-1860fbc21a774caa8f042fe51c35ad03 |
| 出典メモ | uspto-grants-1994_03 |