N-Methylbenzylamine → 3-Methyl-6-[2-(N-methyl-N-benzylamino)ethyl]benzothiazolinone

HRID 487554ノート

反応式

HRID 487554 の反応式
[CH3:1][NH:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH3:10][N:11]1[C:15]2[CH:16]=[CH:17][C:18]([CH2:20][CH2:21]Br)=[CH:19][C:14]=2[S:13](=[O:23])[CH2:12]1>O1CCOCC1>[CH3:10][N:11]1[C:15]2[CH:16]=[CH:17][C:18]([CH2:20][CH2:21][N:2]([CH3:1])[CH2:3][C:4]3[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=3)=[CH:19][C:14]=2[S:13](=[O:23])[CH2:12]1

参加物

4

反応物 2

HCID 7669N-MethylbenzylamineHCID 701838363-Methyl-6-(2-bromoethyl)benzothiazolinone

生成物 1

HCID 678520773-Methyl-6-[2-(N-methyl-N-benzylamino)ethyl]benzothiazolinone

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

0.04 mol of N-methyl-N-benzylamine and 0.02 mol of 3-methyl-6-(2-bromoethyl)benzothiazolinone, the latter being dissolved beforehand in 120 cm3 of dioxane, are introduced into a 100-cm3 ground-necked flask fitted with a reflux condenser. The mixture is heated to reflux for 96 hours with magnetic stirring. After cooling, the reaction mixture is filtered and the filtrate is then evaporated on a water bath under vacuum. The residue is taken up with 50 cm3 and alkalinized with 10 cm3 of normal sodium hydroxide solution.

後処理

  1. additionare introduced into a 100-cm3 ground-necked flask
  2. customfitted with a reflux condenser
  3. temperatureThe mixture is heated
  4. temperatureto reflux for 96 hours with magnetic stirring
  5. temperatureAfter cooling
  6. filtrationthe reaction mixture is filtered
  7. customthe filtrate is then evaporated on a water bath under vacuum

出典と根拠

ORDレコード
ord-381d1dd372974a9e81cd0ae81d0da1dd
出典データセット
uspto-grants-1994_03
特許番号
US05296477

反応ノート

読み込み中…