Hydrochloric Acid → 4-Methoxymethyl-2-nitrobenzoic acid
反応式
Cl[CH2:2][C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9]C)=[O:8])=[C:5]([N+:13]([O-:15])=[O:14])[CH:4]=1.[CH3:16][O-:17].[Na+].CO.O.Cl>CO>[CH3:16][O:17][CH2:2][C:3]1[CH:12]=[CH:11][C:6]([C:7]([OH:9])=[O:8])=[C:5]([N+:13]([O-:15])=[O:14])[CH:4]=1参加物
6
実験手順
A mixture of methyl 4-chloromethyl-2-nitrobenzoate (1.6 g), 28% sodium methoxide-methanol solution (2.5 ml) in methanol (16 ml) was stirred under reflux for 24 hours. To this mixture, water (5 ml) was added and the mixture was stirred for 2 hours, acidified with 1N hydrochloric acid, extracted with ethyl acetate. The combined organic extract was washed with water, dried over magnesium sulfate and evaporated to give 4-methoxymethyl-2-nitrobenzoic acid (0.84 g).
後処理
- temperatureunder reflux for 24 hours
- stirringthe mixture was stirred for 2 hours
- extractionextracted with ethyl acetate
- extractionThe combined organic extract
- washwas washed with water
- dry with materialdried over magnesium sulfate
- customevaporated
出典と根拠
- ORDレコード
- ord-244636acb22c4a39a1874d387d52cc69
- 出典データセット
- uspto-grants-1994_03
- 特許番号
- US05296487
反応ノート
読み込み中…