4-Tert-butyl-2-[5-(2,2-diethoxycarbonylethyl)benzofuran-2-yl]thiazole → 4-Tert-butyl-2-[5-(2,2-dicarboxyethyl)benzofuran-2-yl]thiazole

HRID 487704ノート

反応式

HRID 487704 の反応式
[C:1]([C:5]1[N:6]=[C:7]([C:10]2[O:11][C:12]3[CH:18]=[CH:17][C:16]([CH2:19][CH:20]([C:26]([O:28]CC)=[O:27])[C:21]([O:23]CC)=[O:22])=[CH:15][C:13]=3[CH:14]=2)[S:8][CH:9]=1)([CH3:4])([CH3:3])[CH3:2]>Cl>[C:1]([C:5]1[N:6]=[C:7]([C:10]2[O:11][C:12]3[CH:18]=[CH:17][C:16]([CH2:19][CH:20]([C:21]([OH:23])=[O:22])[C:26]([OH:28])=[O:27])=[CH:15][C:13]=3[CH:14]=2)[S:8][CH:9]=1)([CH3:4])([CH3:2])[CH3:3]

参加物

3

反応物 1

HCID 190926974-Tert-butyl-2-[5-(2,2-diethoxycarbonylethyl)benzofuran-2-yl]thiazole

生成物 1

HCID 190927654-Tert-butyl-2-[5-(2,2-dicarboxyethyl)benzofuran-2-yl]thiazole収率 27.7%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

A mixture of 4-tert-butyl-2-[5-(2,2-diethoxycarbonylethyl)benzofuran-2-yl]thiazole (3.99 g) and conc. hydrochloric acid (20 ml) was stirred under reflux for 6 hours. After being cooled, the resulting mixture was extracted with ethyl acetate. The extract was allowed to stand until there were no further precipitates separated out. The precipitates were collected by filtration and washed with ethyl acetate to give 4-tert-butyl-2-[5-(2,2-dicarboxyethyl)benzofuran-2-yl]thiazole (0.96 g).

後処理

  1. temperatureunder reflux for 6 hours
  2. temperatureAfter being cooled
  3. extractionthe resulting mixture was extracted with ethyl acetate
  4. customno further precipitates
  5. customseparated out
  6. filtrationThe precipitates were collected by filtration
  7. washwashed with ethyl acetate

出典と根拠

ORDレコード
ord-79e832f0fa3b43a795750c260e9bf939
出典データセット
uspto-grants-1994_03
特許番号
US05296495

反応ノート

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