Hydrochloric Acid → HCID 19093039、化合物

HRID 487725ノート

反応式

HRID 487725 の反応式
[ClH:1].C([N:5]1[CH2:10][CH2:9][C:8]2[S:11][C:12]([C:15]([O:17][CH3:18])=[O:16])=[C:13]([NH2:14])[C:7]=2[CH2:6]1)(=O)C>CO>[ClH:1].[NH2:14][C:13]1[C:7]2[CH2:6][NH:5][CH2:10][CH2:9][C:8]=2[S:11][C:12]=1[C:15]([O:17][CH3:18])=[O:16]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 19093041HCID 19093041、化合物

生成物 1

HCID 19093039HCID 19093039、化合物収率 68%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

20 ml of methanol and then 5.1 ml of concentrated hydrochloric acid were added to 2.54 g of methyl 5-acetyl-3-amino-4,5,6,7tetrahydrothieno[3,2-c]pyridine-2-carboxylate (Compound No. 16) obtained in Example 1. The resultant mixture was heated under reflux for 4 hours. After cooling, the crystals thus formed were taken by filtration to obtain 1.70 g (68%) of methyl 3-amino-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate hydrochloride.

後処理

  1. custom16) obtained in Example 1
  2. temperatureunder reflux for 4 hours
  3. temperatureAfter cooling
  4. customthe crystals thus formed
  5. filtrationwere taken by filtration

出典と根拠

ORDレコード
ord-a0bc80d4251f45c3b78165ddbb33391a
出典データセット
uspto-grants-1994_03
特許番号
US05296603

反応ノート

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