4-acetyl-5-methyl-2-phenyloxazole N-oxide hydrochloride → 1-(5-Methyl-2-phenyl-1,3-oxazol-4-yl)ethan-1-one
反応式
Cl.[C:2]([C:5]1[N+:6]([O-])=[C:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[O:8][C:9]=1[CH3:10])(=[O:4])[CH3:3]>C(O)(=O)C.[Zn]>[C:2]([C:5]1[N:6]=[C:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[O:8][C:9]=1[CH3:10])(=[O:4])[CH3:3]参加物
4
実験手順
Next, 100 g of 4-acetyl-5-methyl-2-phenyloxazole N-oxide hydrochloride was dissolved in 500 ml of glacial acetic acid and 100 g of zinc powder was added to the solution while cool stirring within a ice water bath. The separation was filtered after addition of 2 l of water and recrystalization was carried out by addition of methanol to produce 10 g of 4-acetyl-5-methyl-2-phenyloxazole (melting point; 74° to 76° C.).
後処理
- temperaturewhile cool
- customThe separation
- filtrationwas filtered
- additionafter addition of 2 l of water and recrystalization
- additionwas carried out by addition of methanol
出典と根拠
- ORDレコード
- ord-22b2523d82a0402698f11211b08c1e18
- 出典データセット
- uspto-grants-1994_03
- 特許番号
- US05296607
反応ノート
読み込み中…