化工社化工社 化学情報印刷レポート · 研究参考用
1-Chloro-2-(trifluoromethyl)benzene → 2-Trifluoromethylbenzoic acid, 4-methoxyphenyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Chloro-2-(trifluoromethyl)benzene | HCID 6921 | — |
| 反応物 | 4-Methoxyphenol | HCID 9015 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 1,4-Bis(diphenylphosphino)butane | HCID 82124 | — |
| 反応物 | HCID 178418416 | HCID 178418416 | — |
| 触媒 | Palladium Chloride | HCID 24290 | — |
| 生成物 | 2-Trifluoromethylbenzoic acid, 4-methoxyphenyl ester | HCID 532426 | — |
反応手順
In an autoclave made of a metal were placed 45.13 g of ortho-chlorobenzotrifluoride, 6.2 g of para-methoxyphenol, 88.5 mg of palladium chloride, 213 mg of 1,4-bisdiphenylphosphinobutane and 5.3 g of sodium carbonate. The air in the autoclave was replaced with carbon monoxide introduced thereinto in several times, after which carbon monoxide was further introduced to adjust its pressure therein to 30 kg/cm2. The internal temperature was adjusted to 190° C. on a salt bath and the reaction was carried out thereon with stirring for 5 hours.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05296601 |
| 出典データセット | uspto-grants-1994_03 |
| ORD ID | ord-d55c1ac288e24512823a757050b66de0 |
| 出典メモ | uspto-grants-1994_03 |