化工社化工社 化学情報印刷レポート · 研究参考用
Methylamine → (E)-N-methyl-6,6-dimethyl-2-hepten-4-ynylamine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methylamine | HCID 6329 | — |
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | 3,3-Dimethyl-1-butyne | HCID 13512 | — |
| 反応物 | 1,3-Dichloropropene | HCID 24883 | — |
| 触媒 | Palladium Chloride | HCID 24290 | — |
| 触媒 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | (E)-N-methyl-6,6-dimethyl-2-hepten-4-ynylamine hydrochloride | HCID 19917487 | 70% |
反応手順
By using 104 ml (3.02 mol) of 40% methylamine aqueous solution instead of n-propylamine, 85 ml of tetrahydrofuran, 9.10 ml (98.8 mmol) of 1,3-dichloropropene (E/Z =9/1), 950 mg (5 mmol) of copper (I) iodide, 355 mg (2 mmol) of palladium chloride, 1.05 g (4 mmol) of triphenylphosphine and 15.0 ml (0.121 mol) of tert-butylacetylene, the treatment was conducted in the same manner as in Example 1 to obtain 12.9 g (yield: 70%) of the above identified compound as off-white crystalline powder.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05296612 |
| 出典データセット | uspto-grants-1994_03 |
| ORD ID | ord-be081e966b924843907e67a4b92e6cb2 |
| 出典メモ | uspto-grants-1994_03 |