化工社化工社 化学情報印刷レポート · 研究参考用
2-Bromobenzyl bromide → 1-Bromo-2-(methoxymethyl)benzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Bromobenzyl bromide | HCID 76965 | — |
| 反応物 | Sodium Methoxide | HCID 10942334 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 1-Bromo-2-(methoxymethyl)benzene | HCID 12927162 | — |
反応手順
685 g (2.74 mol) of o-bromobenzyl bromide was refluxed with 2.74 mol of a 30% strength sodium methylate solution in methanol for 15 hours. After the mixture had cooled to room temperature it was evaporated down, taken up in ethyl acetate, and washed with water. After the organic phase had been dried over sodium sulfate, it was again evaporated down. There was obtained 478.2 g (87%) of the title substance as a colorless liquid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05298527 |
| 出典データセット | uspto-grants-1994_03 |
| ORD ID | ord-c3460ea5355a4863a64497f82519f589 |
| 出典メモ | uspto-grants-1994_03 |