Water → (E)-1-[3-(5-ethyl-4-hydroxy-3-methoxy-1-naphthyl)-1-oxo-2-propenyl]piperidine

HRID 488148ノート

反応式

HRID 488148 の反応式
[CH2:1]([C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[C:5]([O:25]COC)=[C:6]([O:23][CH3:24])[CH:7]=[C:8]2/[CH:13]=[CH:14]/[C:15]([N:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1)=[O:16])[CH3:2].O>CC(C)=O.Cl>[CH2:1]([C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[C:5]([OH:25])=[C:6]([O:23][CH3:24])[CH:7]=[C:8]2/[CH:13]=[CH:14]/[C:15]([N:17]1[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]1)=[O:16])[CH3:2]

参加物

5

反応物 2

HCID 962WaterHCID 14986472(E)-1-[3-(5-ethyl-3-methoxy-4-methoxymethoxy-1-naphthyl)-1-oxo-2-propenyl]piperidine

生成物 1

HCID 14986482(E)-1-[3-(5-ethyl-4-hydroxy-3-methoxy-1-naphthyl)-1-oxo-2-propenyl]piperidine収率 89.4%

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 313Hydrochloric Acid溶媒

実験手順

960 mg of (E)-1-[3-(5-ethyl-3-methoxy-4-methoxymethoxy-1-naphthyl)-1-oxo-2-propenyl]piperidine was dissolved in 50 ml of acetone, to which 1 ml of concentrated hydrochloric acid was gradually added at room temperature. After stirring at room temperature for 5 hours, the reaction mixture was slowly poured into water. The resultant crystals were collected by filtration, washed with water and dried to obtain 760 mg of the titled compound as yellow crystals.

後処理

  1. additionwas gradually added at room temperature
  2. filtrationThe resultant crystals were collected by filtration
  3. washwashed with water
  4. customdried

出典と根拠

ORDレコード
ord-2b7b0b8b3b4a4007aa8f80804f8e2253
出典データセット
uspto-grants-1994_03
特許番号
US05298649

反応ノート

読み込み中…