Methyl morpholine oxide → 4-Phenyl-3-furaldehyde

HRID 488241

反応式

HRID 488241 の反応式
[C:1]1([C:7]2[C:11]([CH2:12][OH:13])=[CH:10][O:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C[N+]1([O-])CCOCC1>ClCCl.[Ru]([O-])(=O)(=O)=O.C([N+](CCC)(CCC)CCC)CC>[C:1]1([C:7]2[C:11]([CH:12]=[O:13])=[CH:10][O:9][CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

5

反応物 2

HCID 82029Methyl morpholine oxideHCID 15037154(4-Phenylfuran-3-yl)methanol2 回

生成物 1

HCID 150371484-Phenyl-3-furaldehyde

試薬・触媒・溶媒 2

HCID 178419074HCID 178419074、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

A mixture of 3-phenyl-4-furylmethanol (Compound 19, 458 mg, 2.63 mmol), powdered 4A molecular sieves (500 mg), 4-methyl-morpholine-N-oxide (462 mg, 3.95 mmol) and tetrapropylammonium perruthenate (46 mg, 0.13 mmol) in anhydrous dichloromethane (40 ml) were stirred at room temperature for 3 hours. Residue was filtered through silica and concentrated to a brown oil which was purified by flash chromatography on silica using 10% ethyl ether/hexanes to give the titled aldehyde.

後処理

  1. filtrationResidue was filtered through silica
  2. concentrationconcentrated to a brown oil which
  3. customwas purified by flash chromatography on silica using 10% ethyl ether/hexanes

出典と根拠

ORDレコード
ord-f25d39c3e0214fe99b24cd420b86fba7
出典データセット
uspto-grants-1994_03
特許番号
US05298633

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