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Methyl 4-nitropyridine-2-carboxylate → Methyl 4-aminopyridine-2-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 4-nitropyridine-2-carboxylate | HCID 3352523 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Methyl 4-aminopyridine-2-carboxylate | HCID 3759117 | 94.1% |
反応手順
A solution of methyl 4-nitropyridin-2-ylcarboxylate (0.7 g) (Deady et. al., Aus. J. Chem. 24 (1971)385-390) in methanol (30 ml) was treated with 10% Pd/C (0.3 g) and stirred under hydrogen at atmospheric pressure overnight. The solution was filtered and evaporated to yield the title compound (0.55 g). NMR δ(CDCl3) 3.97(3H,s), 4.34(2H, broad), 6.65(1H,dd), 7.39(1H,d), 8.32(1H,d).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06972297B2 |
| 出典データセット | uspto-grants-2005_12 |
| ORD ID | ord-7f1060c725a74a8e9560e611ae4b9716 |
| 出典メモ | uspto-grants-2005_12 |