Hydrochloric Acid → Ethyl 6-(methylamino)-3-pyridazinecarboxylate

HRID 488461ノート

反応式

HRID 488461 の反応式
[CH3:1][NH:2][C:3]1[N:4]=[N:5][C:6]([C:9]([OH:11])=[O:10])=[CH:7][CH:8]=1.Cl.[CH2:13](O)[CH3:14]>>[CH3:1][NH:2][C:3]1[N:4]=[N:5][C:6]([C:9]([O:11][CH2:13][CH3:14])=[O:10])=[CH:7][CH:8]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 222714356-(Methylamino)pyridazine-3-carboxylic Acid

生成物 1

HCID 22271465Ethyl 6-(methylamino)-3-pyridazinecarboxylate

実験手順

A solution of 3-methylaminopyridazine-6-carboxylic acid (0.58 g) in ethanol (50 ml) was saturated with HCl gas, refluxed 48 hours and evaporated. The residue was partitioned between EtOAc and aqueous NaHCO3, separated and the aqueous re-extracted with EtOAc. The organic was dried and evaporated to give title compound (0.61 g). MS(+ve ion chemical ionisation) m/z 182 (MH+, 100%).

後処理

  1. temperaturerefluxed 48 hours
  2. customevaporated
  3. customThe residue was partitioned between EtOAc and aqueous NaHCO3
  4. customseparated
  5. extractionthe aqueous re-extracted with EtOAc
  6. customThe organic was dried
  7. customevaporated

出典と根拠

ORDレコード
ord-a04624f73001438ab890b608c3aae5d7
出典データセット
uspto-grants-2005_12
特許番号
US06972297B2

反応ノート

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