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Diethylamine → 4-[(Diethylamino)methyl]benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethylamine | HCID 8021 | — |
| 反応物 | 4-(Chloromethyl)benzoic acid | HCID 74234 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 4-[(Diethylamino)methyl]benzoic acid | HCID 948516 | 63% |
反応手順
1 g (1 equivalent) of α-chloroparatoluic acid and 1.22 mL (2 equivalents) of diethylamine are placed in solution in 30 mL of acetonitrile. The reaction mixture is taken to reflux for 48 hours. The solvent is evaporated off under vacuum and the residue is purified by chromatography on silica gel column (CH2Cl2/MeOH 60/40 then pure MeOH). The product is obtained in the form of a white powder after precipitation from hexane. (Yield=63%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06972343B1 |
| 出典データセット | uspto-grants-2005_12 |
| ORD ID | ord-67b3606ed97745088224a32eb7d53c20 |
| 出典メモ | uspto-grants-2005_12 |