1,1'-(Diazomethylene)bis(benzene) → Benzhydryl 2-{4-[2-(acetylamino)-3-(allyloxy)-3-oxopropyl][tert-butoxy(oxo)acetyl]-2-ethylanilino}benzoate
反応式
[C:1]([NH:4][CH:5]([C:34]([O:36][CH2:37][CH:38]=[CH2:39])=[O:35])[CH2:6][C:7]1[CH:31]=[CH:30][C:10]([N:11]([C:21](=[O:29])[C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[C:12]2[CH:20]=[CH:19][CH:18]=[CH:17][C:13]=2[C:14]([OH:16])=[O:15])=[C:9]([CH2:32][CH3:33])[CH:8]=1)(=[O:3])[CH3:2].[C:40]1([C:46]([C:49]2[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=2)=[N+]=[N-])[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1>CC(C)=O>[C:1]([NH:4][CH:5]([C:34]([O:36][CH2:37][CH:38]=[CH2:39])=[O:35])[CH2:6][C:7]1[CH:31]=[CH:30][C:10]([N:11]([C:21](=[O:29])[C:22]([O:24][C:25]([CH3:27])([CH3:28])[CH3:26])=[O:23])[C:12]2[CH:20]=[CH:19][CH:18]=[CH:17][C:13]=2[C:14]([O:16][CH:46]([C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)[C:49]2[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=2)=[O:15])=[C:9]([CH2:32][CH3:33])[CH:8]=1)(=[O:3])[CH3:2]参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
To 2-{4-[2-(acetylamino)-3-(allyloxy)-3-oxopropyl][tert-butoxy(oxo)acetyl]-2-ethylanilino}benzoic acid in acetone was added diphenyldiazomethane (until all starting material was consumed as evident by monitoring via TLC). The reaction mixture was concentrated under reduced pressure, purified on silica gel using ethyl acetate as eluent to provide the titled compound. MS (ESI(+)) m/e 705 (M+H)+; 1H NMR (300 MHz, DMSO-d6) δ 8.51-8.01 (m, 2H), 7.73-6.86 (m, 16H), 5.93-5.78 (m, 1H), 5.34-5.10 (m, 2H), 4.57-4.40 (m, 3H), 3.10-2.84 (m, 2H), 2.58-2.42 (m, 2H), 1.82-1.77 (m, 3H), 1.22-0.78 (m, 3H), 1.07, 1.05, 1.00 (s, s, s, 9H).