Bromine → 2-(2-Amino-5-bromo-phenyl)-ethanol

HRID 488654

反応式

HRID 488654 の反応式
[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[CH2:4][CH2:5][OH:6].[Br:11]Br>C(O)(=O)C>[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][C:3]=1[CH2:4][CH2:5][OH:6]

参加物

4

反応物 2

HCID 24408BromineHCID 79282o-Aminophenethyl alcohol

生成物 1

HCID 219968352-(2-Amino-5-bromo-phenyl)-ethanol収率 100.3%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒3 回

実験手順

To a solution of 2-aminophenethyl alcohol (10.0 g, 72.9 mmol) in acetic acid (60 mL) at 10° C. was added Br2 (3.8 mL, 72.9 mmol) in acetic acid (5 mL). Additional acetic acid (30 mL) was added and the reaction was stirred for 1 hour. The mixture was filtered and the filter cake washed with diethyl ether. The solid was then partitioned between ethyl acetate and aqueous 3N NaOH. The organic layer was washed with brine, dried (Na2SO4), filtered and concentrated under reduced pressure to provide the titled compound (15.8 g).

後処理

  1. filtrationThe mixture was filtered
  2. washthe filter cake washed with diethyl ether
  3. customThe solid was then partitioned between ethyl acetate and aqueous 3N NaOH
  4. washThe organic layer was washed with brine
  5. dry with materialdried (Na2SO4)
  6. filtrationfiltered
  7. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-08e4b1d43a0b4c74983299ec1bcc6281
出典データセット
uspto-grants-2005_12
特許番号
US06972340B2

関連ノート

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