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Methyl 2-{4-[(tert-butoxycarbonyl)amino]butoxy}-6-hydroxybenzoate → Trifluoroacetic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 2-{4-[(tert-butoxycarbonyl)amino]butoxy}-6-hydroxybenzoate | HCID 10980693 | — |
| 反応物 | Trifluoroacetic acid methylene chloride | HCID 21863450 | — |
| 生成物 | Trifluoroacetic acid | HCID 6422 | — |
| 生成物 | Methyl 2-(4-aminobutoxy)-6-hydroxybenzoate | HCID 11832643 | — |
反応手順
Methyl 2-{4-[(tert-butoxycarbonyl)amino]butoxy}-6-hydroxybenzoate (410 mg, 1.2 mmol) was treated with trifluoroacetic acid/dichloromethane (6 mL, 1:1/v:v) at ambient temperature for 3 hours, concentrated under reduced pressure and evaporated with acetonitrile twice to provide the titled amine as its trifluoroacetic acid salt (450 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06972340B2 |
| 出典データセット | uspto-grants-2005_12 |
| ORD ID | ord-568236dc42d244379cbec0ebfbe7e366 |
| 出典メモ | uspto-grants-2005_12 |