Methyl 2-{4-[(tert-butoxycarbonyl)amino]butoxy}-6-hydroxybenzoate → Trifluoroacetic acid

HRID 488658

反応式

HRID 488658 の反応式
C(OC([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14]1[CH:23]=[CH:22][CH:21]=[C:20]([OH:24])[C:15]=1[C:16]([O:18][CH3:19])=[O:17])=O)(C)(C)C.[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28].ClCCl>>[NH2:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14]1[CH:23]=[CH:22][CH:21]=[C:20]([OH:24])[C:15]=1[C:16]([O:18][CH3:19])=[O:17].[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28]

参加物

4

反応物 2

HCID 10980693Methyl 2-{4-[(tert-butoxycarbonyl)amino]butoxy}-6-hydroxybenzoateHCID 21863450Trifluoroacetic acid methylene chloride

生成物 2

HCID 6422Trifluoroacetic acidHCID 11832643Methyl 2-(4-aminobutoxy)-6-hydroxybenzoate

実験手順

Methyl 2-{4-[(tert-butoxycarbonyl)amino]butoxy}-6-hydroxybenzoate (410 mg, 1.2 mmol) was treated with trifluoroacetic acid/dichloromethane (6 mL, 1:1/v:v) at ambient temperature for 3 hours, concentrated under reduced pressure and evaporated with acetonitrile twice to provide the titled amine as its trifluoroacetic acid salt (450 mg).

後処理

  1. concentrationconcentrated under reduced pressure
  2. customevaporated with acetonitrile twice

出典と根拠

ORDレコード
ord-568236dc42d244379cbec0ebfbe7e366
出典データセット
uspto-grants-2005_12
特許番号
US06972340B2

関連ノート

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