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HRID 488682作成日:2026年10月24日

Hydrochloric Acid → Methyl 3-(4-aminobutoxy)-1-hydroxy-2-naphthoate

https://huagongshe.com/ja/reaction/488682

反応式

関与物質

役割名称HCID仕込み量
反応物Hydrochloric AcidHCID 313—
反応物Methyl 3-{4-[(tert-butoxycarbonyl)amino]butoxy}-1-(methoxymethoxy)-2-naphthoateHCID 22271972—
溶媒1,4-DioxaneHCID 31275—
生成物Methyl 3-(4-aminobutoxy)-1-hydroxy-2-naphthoateHCID 22271969102.6%

反応手順

To a mixture of methyl 3-{4-[(tert-butoxycarbonyl)amino]butoxy}-1-(methoxymethoxy)-2-naphthoate (28 mg, 0.064 mmol) was added 4M HCl in dioxane (1 mL). The mixture was stirred at ambient temperature for 30 minutes, concentrated under reduced pressure to provide the titled compound (19 mg, 100%) as its hydrochloride salt.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06972340B2
出典データセットuspto-grants-2005_12
ORD IDord-5eae51615e85413895203e397774bdcf
出典メモuspto-grants-2005_12