Hydrochloric Acid → Methyl 3-(4-aminobutoxy)-1-hydroxy-2-naphthoate

HRID 488682

反応式

HRID 488682 の反応式
C(OC([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14]1[C:15]([C:28]([O:30][CH3:31])=[O:29])=[C:16]([O:24]COC)[C:17]2[C:22]([CH:23]=1)=[CH:21][CH:20]=[CH:19][CH:18]=2)=O)(C)(C)C.Cl>O1CCOCC1>[NH2:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14]1[C:15]([C:28]([O:30][CH3:31])=[O:29])=[C:16]([OH:24])[C:17]2[C:22]([CH:23]=1)=[CH:21][CH:20]=[CH:19][CH:18]=2

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 22271972Methyl 3-{4-[(tert-butoxycarbonyl)amino]butoxy}-1-(methoxymethoxy)-2-naphthoate

生成物 1

HCID 22271969Methyl 3-(4-aminobutoxy)-1-hydroxy-2-naphthoate収率 102.6%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

To a mixture of methyl 3-{4-[(tert-butoxycarbonyl)amino]butoxy}-1-(methoxymethoxy)-2-naphthoate (28 mg, 0.064 mmol) was added 4M HCl in dioxane (1 mL). The mixture was stirred at ambient temperature for 30 minutes, concentrated under reduced pressure to provide the titled compound (19 mg, 100%) as its hydrochloride salt.

後処理

  1. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-5eae51615e85413895203e397774bdcf
出典データセット
uspto-grants-2005_12
特許番号
US06972340B2

関連ノート

読み込み中…