4,5-Dimethyl-1H-imidazole → 2,3-Dimethyl-8-(2,4-dichlorophenyl)-5,6-dihydroimidazo[1,2-a]pyridine
反応式
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]([CH:11]1[CH2:13][CH2:12]1)=O.[CH3:14][C:15]1[N:16]=[CH:17][NH:18][C:19]=1[CH3:20]>C(OCC)(=O)C>[CH3:14][C:15]1[N:16]=[C:17]2[C:9]([C:3]3[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=3[Cl:1])=[CH:11][CH2:13][CH2:12][N:18]2[C:19]=1[CH3:20]参加物
4
反応条件
- 温度
- 205 °C
実験手順
Cyclopropyl 2,4-dichlorophenyl ketone (1) (54 g, 0.25 mol) and 4,5-dimethylimidazole (2) (90 g, 1 mol) are combined and heated at 200 to 210° C. under nitrogen for 20 hours. The reaction is cooled and diluted with ethyl acetate (700 ml). The ethyl acetate solution is washed with saturated aq potassium carbonate (300 ml) and water (4×200 ml) and dried over sodium sulfate. The drying agent is removed by filtration and the solvent is removed in vacuo to provide 3.