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Cyclohexane → 3-(3-bromopropyl)-1H-indole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cyclohexane | HCID 8078 | — |
| 反応物 | Triphenylphosphine dibromide | HCID 70579 | — |
| 反応物 | Indole-3-propanol | HCID 77115 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 3-(3-bromopropyl)-1H-indole | HCID 10037192 | 99.4% |
反応手順
To a solution of 2 g (11.41 mmol) of 3-(1H-indol-3-yl)propanol in 40 ml of dioxane was added at room temperature 5.3 g (12.55 mmol) of dibromotriphenylphosphorane and the resulting solution was stirred during 18 h. An excess of cyclohexane was added and the resulting precipitate was filtered and discarded. The solvent was evaporated to dryness to give 2.7 g (99%) of product as an oil which was used in the subsequent step without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06974819B2 |
| 出典データセット | uspto-grants-2005_12 |
| ORD ID | ord-eeb14de8206a4951914cf43bcae514b2 |
| 出典メモ | uspto-grants-2005_12 |