Cesium carbonate → HCID 69733830、化合物

HRID 488780ノート

反応式

HRID 488780 の反応式
[Br:1][C:2]1[N:11]=[C:10]2[C:5]([CH:6]=[C:7]([OH:12])[N:8]=[CH:9]2)=[CH:4][CH:3]=1.Br[CH2:14][C:15]1[CH:24]=[CH:23][C:18]([C:19]([O:21][CH3:22])=[O:20])=[CH:17][CH:16]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C)C=O>[CH3:22][O:21][C:19](=[O:20])[C:18]1[CH:23]=[CH:24][C:15]([CH2:14][N:8]2[C:7](=[O:12])[CH:6]=[C:5]3[C:10]([N:11]=[C:2]([Br:1])[CH:3]=[CH:4]3)=[CH:9]2)=[CH:16][CH:17]=1

参加物

5

反応物 3

HCID 10796Cesium carbonateHCID 256687Methyl 4-(bromomethyl)benzoateHCID 178515313HCID 178515313、化合物

生成物 1

HCID 69733830HCID 69733830、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

The alkylation of 7-bromo-3-hydroxy-8-azaisoquinoline (1.00 g, 4.46 mmol) using methyl 4-(bromomethyl)benzoate (1.53 g, 6.69 mmol) and cesium carbonate (2.18 g, 6.69 mmol) in dimethylformamide is carried out as previously described in Example 1, Step (1). The solid is crystallized from hexanes/ethyl acetate 2:1, the white crystals collected by filtration and dried to give the desired product.

後処理

  1. customThe solid is crystallized from hexanes/ethyl acetate 2:1
  2. filtrationthe white crystals collected by filtration
  3. customdried

出典と根拠

ORDレコード
ord-427f53e318c34bf0a1268facf5fb49fb
出典データセット
uspto-grants-2005_12
特許番号
US06974822B2

反応ノート

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