Hydrochloric Acid → Sibutramine Hydrochloride

HRID 488807ノート

反応式

HRID 488807 の反応式
[CH3:1][CH:2]([CH2:4][CH:5]([N:17]([CH3:19])[CH3:18])[C:6]1([C:10]2[CH:11]=[CH:12][C:13]([Cl:16])=[CH:14][CH:15]=2)[CH2:9][CH2:8][CH2:7]1)[CH3:3].[ClH:20]>CC(OC)(C)C.C(OCC)C>[CH3:3][CH:2]([CH2:4][CH:5]([N:17]([CH3:18])[CH3:19])[C:6]1([C:10]2[CH:11]=[CH:12][C:13]([Cl:16])=[CH:14][CH:15]=2)[CH2:7][CH2:8][CH2:9]1)[CH3:1].[ClH:20]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 5210Sibutramine

生成物 1

HCID 64764Sibutramine Hydrochloride

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 15413tert-Butyl methyl ether溶媒

実験手順

Sibutramine free base (2.25 g) was dissolved in MTBE (20 mL) and that solution was added to 20 mL 1M HCl in diethyl ether. The reaction mixture was stinted for 30 minutes, and the solid was collected by filtration to give 1.73 g after drying. The product was characterized by 1H NMR.

後処理

  1. filtrationthe solid was collected by filtration
  2. customto give 1.73 g
  3. customafter drying

出典と根拠

ORDレコード
ord-d02c7c80e8ac461985487319128e9fb5
出典データセット
uspto-grants-2005_12
特許番号
US06974837B2

反応ノート

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