Dimethyl Sulfate → 3-Bromo-4,5-dimethoxybenzaldehyde
反応式
[Br:1][C:2]1[C:3]([OH:12])=[C:4]([O:10][CH3:11])[CH:5]=[C:6]([CH:9]=1)[CH:7]=[O:8].[C:13](=O)([O-])[O-].[K+].[K+].COS(OC)(=O)=O>CC(C)=O.C(OCC)(=O)C>[Br:1][C:2]1[CH:9]=[C:6]([CH:5]=[C:4]([O:10][CH3:11])[C:3]=1[O:12][CH3:13])[CH:7]=[O:8]参加物
6
実験手順
To a solution of 5-bromovanillin (2.00 g, 8.65 mmol) in acetone (50 mL) was added potassium carbonate (1.4 g, 10.38 mmol) and dimethylsulfate (1 mL, 10.38 mmol). The solution was stirred at room temperature for 16 hours. The reaction mixture was diluted with ethyl acetate and the organic layer was washed successively with water and brine, dried over anhydrous magnesium sulfate, filtered and evaporated to afford 1.88 g of 3-bromo-4,5-dimethoxybenzaldehyde (89%).
後処理
- washthe organic layer was washed successively with water and brine
- dry with materialdried over anhydrous magnesium sulfate
- filtrationfiltered
- customevaporated
出典と根拠
- ORDレコード
- ord-c76798833fc6472b8a037b56a9eede7b
- 出典データセット
- uspto-grants-2005_12
- 特許番号
- US06974826B2
反応ノート
読み込み中…