2-Bromoacetamide → 3-Amino-6-isobutyl-4-methyl-thieno[2,3-b]pyridine-2-carboxylic acid amide

HRID 488911ノート

反応式

HRID 488911 の反応式
[CH2:1]([C:5]1[CH:12]=[C:11]([CH3:13])[C:8]([C:9]#[N:10])=[C:7]([SH:14])[N:6]=1)[CH:2]([CH3:4])[CH3:3].Br[CH2:16][C:17]([NH2:19])=[O:18].[O-]CC.[Na+]>CN(C=O)C.O>[NH2:10][C:9]1[C:8]2[C:7](=[N:6][C:5]([CH2:1][CH:2]([CH3:4])[CH3:3])=[CH:12][C:11]=2[CH3:13])[S:14][C:16]=1[C:17]([NH2:19])=[O:18]

参加物

6

反応物 3

HCID 696322-BromoacetamideHCID 2723922Sodium ethoxideHCID 178425008HCID 178425008、化合物

生成物 1

HCID 100384143-Amino-6-isobutyl-4-methyl-thieno[2,3-b]pyridine-2-carboxylic acid amide収率 39.1%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

反応条件

温度
70 °C

実験手順

A mixture of the above nitrile (1.00 g, 4.85 mmol), bromoacetamide (0.67 g, 4.85 mmol), and sodium ethoxide (0.68 g, 10 mmol) in DMF (20 mL) was heated at 70° C. for 1 h before it was allowed to cool to room temperature. The resulting mixture was diluted with water, filtrated and the precipitates washed with ETOH providing the title compound (0.5 g, 39%).

後処理

  1. temperatureto cool to room temperature
  2. filtrationfiltrated
  3. washthe precipitates washed with ETOH

出典と根拠

ORDレコード
ord-8447fc6919784333bcd5301c3a4286f9
出典データセット
uspto-grants-2005_12
特許番号
US06974870B2

反応ノート

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