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Potassium Phosphate, Tribasic → Butanoic acid, 4-chloro-3-hydroxy-, ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Phosphate, Tribasic | HCID 62657 | — |
| 反応物 | Ethyl 4-chloroacetoacetate | HCID 69484 | — |
| 反応物 | (R)-2-Octanol | HCID 80080 | — |
| 反応物 | Nadh | HCID 439153 | — |
| 生成物 | Butanoic acid, 4-chloro-3-hydroxy-, ethyl ester | HCID 4377704 | — |
反応手順
100 mM potassium phosphate buffer (pH 6.5), 139.8 mg NADH, 0.06 U (R)-2-octanol dehydrogenase from Candida utilis, and 0.5% 4-chloroacetoacetic acid ethyl ester were reacted overnight at 30° C. The optical purity of the 4-chloro-3-hydroxybutyric acid ethyl ester produced was determined in the same way as Example 32. As a result, 4-chloro-3-hydroxybutyric acid ethyl ester produced by this invention was more than 97% ee of S form.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06706507B2 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-2b07d62153c34136b1cec522d67e3f89 |
| 出典メモ | uspto-grants-2004_03 |