Glyceraldehyde → Benzyl 4,5-dihydroxy-2-pentenoate

HRID 489063

反応式

HRID 489063 の反応式
[CH2:1]([OH:6])[CH:2]([OH:5])[CH:3]=O.[Br-].[CH2:8]([O:15][C:16]([CH2:18][P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)=[O:17])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>O1C(CC)C1>[OH:5][CH:2]([CH2:1][OH:6])[CH:3]=[CH:18][C:16]([O:15][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:17]

参加物

4

反応物 2

HCID 751GlyceraldehydeHCID 11214019(Benzyloxycarbonylmethyl)triphenylphosphonium bromide

生成物 1

HCID 54529065Benzyl 4,5-dihydroxy-2-pentenoate

試薬・触媒・溶媒 1

HCID 78341,2-Epoxybutane溶媒

実験手順

A mixture of DL-glycerinaldehyde (4.5 g, 50 mmole) and (benzyloxycarbonylmethyl)-triphenyl-phosphoniumbromide (24.57 g, 50 mmole) in 100 ml 1,2-epoxybutane was refluxed overnight. The mixture was evaporated under vacuum and the product was isolated by silica gel column chromatography.

後処理

  1. temperaturewas refluxed overnight
  2. customThe mixture was evaporated under vacuum
  3. customthe product was isolated by silica gel column chromatography

出典と根拠

ORDレコード
ord-274a806608864003b6ffad9050318002
出典データセット
uspto-grants-2005_12
特許番号
US06974802B2

関連ノート

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