関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 反応物 | FMOC-L-valine | HCID 688217 | — |
| 反応物 | Benzyl 4,5-dihydroxy-2-pentenoate | HCID 54529065 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Benzyl 5-(N-FMOC-L-valyloxy)-4-hydroxy-2-pentenoate | HCID 54039988 | — |
反応手順
A mixture of benzyl 4,5-dihydroxy-2-pentenoate (4.4 g, 20 mmole), N-FMOC-L-valine (5.8 g, 17 mmole) and DMAP (0.21 g, 1.7 mmole) in 100 ml dichloromethane was cooled to about 10° C. A solution of DCC (4.2 g, 20 mmole) in 25 ml dichloromethane was added dropwise at the same temperature and the mixture was stirred overnight at room temperature. The mixture was cooled to 5° C. and the urethane was filtered. The filtrate was evaporated under reduced pressure and the product was isolated by silica gel column chromatography.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06974802B2 |
|---|
| 出典データセット | uspto-grants-2005_12 |
|---|
| ORD ID | ord-2bd9dcf911874b48baa6e271c7418ec1 |
|---|
| 出典メモ | uspto-grants-2005_12 |
|---|
