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Dicyclohexylcarbodiimide → benzyl-2-(N-FMOC-L-valyloxy)stearate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 反応物 | FMOC-L-valine | HCID 688217 | — |
| 反応物 | Benzyl 2-hydroxystearate | HCID 22035791 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | benzyl-2-(N-FMOC-L-valyloxy)stearate | HCID 23387558 | — |
反応手順
To a solution of benzyl-2-hydroxystearate (3.2 g, 8.2 mmole), N-FMOC-L-valine (3.4 g, 10 mmole) and DMAP (0.12 g, 1 mmole) in 80 ml dichloromethane was added a solution of DCC (2.5 g, 12 mmole) and the mixture was stirred overnight at room temperature. The mixture was cooled to 5° C. and the urethane was filtered. The filtrate was evaporated and the product was isolated by silica gel column chromatography. Yield: 4.5 g
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06974802B2 |
| 出典データセット | uspto-grants-2005_12 |
| ORD ID | ord-55e6eab99dea4777903a31eabdd16b09 |
| 出典メモ | uspto-grants-2005_12 |