関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-Methyloxybenzyl chloride | HCID 69993 | — |
| 反応物 | 2,2-Dimethyl-4-pentenoic acid | HCID 140065 | — |
| 反応物 | Potassium tert-butoxide | HCID 23665647 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-Methoxybenzyl 2,2-dimethyl-4-pentenoate | HCID 15311349 | 95.8% |
反応手順
To a solution of 2,2-dimethyl-4-pentenoic acid (11.5 g, 90 mmol) in DMF (250 mL) at room temperature, was added potassium tert-butoxide (11.1 g, 99 mmol). The reaction mixture was stirred at 60° C. for 1 h. 4-Methoxybenzylchloride (16.9 g, 108 mmol) was added and the reaction mixture was stirred at 60° C. for 4 h. The DMF was evaporated under vacuum, the residue was dissolved in ether (500 mL) and washed with water (3×200 mL). The organic phase was dried with Na2SO4 and evaporated to give 21.4 g of 4-methoxybenzyl 2,2-dimethyl-4-pentenoate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06974802B2 |
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| 出典データセット | uspto-grants-2005_12 |
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| ORD ID | ord-3432f38a455043e2b19432dd4c6e15a6 |
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| 出典メモ | uspto-grants-2005_12 |
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