Einecs 211-027-4 → 1-Butyl-5,6-dimethyl-3-hydroxy-2-pyridone

HRID 489256ノート

反応式

HRID 489256 の反応式
[Cl-].[NH+]1C=CC=CC=1.[CH2:8]([N:12]1[C:17]([CH3:18])=[C:16]([CH3:19])[CH:15]=[C:14]([O:20]C)[C:13]1=[O:22])[CH2:9][CH2:10][CH3:11]>C(OCC)C>[CH2:8]([N:12]1[C:17]([CH3:18])=[C:16]([CH3:19])[CH:15]=[C:14]([OH:20])[C:13]1=[O:22])[CH2:9][CH2:10][CH3:11]

参加物

4

反応物 2

HCID 69401Einecs 211-027-4HCID 222665381-Butyl-5,6-dimethyl-3-methoxy-2-pyridone

生成物 1

HCID 222665251-Butyl-5,6-dimethyl-3-hydroxy-2-pyridone収率 81.3%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

反応条件

温度
200 °C

実験手順

Pyridinium chloride (293 mg) was added to 1-butyl-5,6-dimethyl-3-methoxy-2-pyridone (1-004-07) (124 mg), and the reaction mixture was heated with stirring in an oil bath at 200° C. under nitrogen atmosphere. After 30 min, the reaction mixture was dissolved in diethyl ether and water, extracted twice with diethyl ether, washed once with water, and dried over magnesium sulfate. The solvent was evaporated under reduced pressure to give 1-butyl-5,6-dimethyl-3-hydroxy-2-pyridone (1-004-08) (94 mg, 81%, m.p.: 112-116° C.)

後処理

  1. temperaturethe reaction mixture was heated
  2. extractionwater, extracted twice with diethyl ether
  3. washwashed once with water
  4. dry with materialdried over magnesium sulfate
  5. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-ed3c71d09bbd48f5b53b86e66b0f4395
出典データセット
uspto-grants-2005_12
特許番号
US06977266B2

反応ノート

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