ethyl 2-bromo-1,4-dimethyl-1H-imidazole-5-carboxylate → 2-(2,6-Dichloro-phenylethynyl)-3,5-dimethyl-3H-imidazole-4-carboxylic acid ethyl ester

反応式

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[C:9]#[CH:10].[CH2:11]([O:13][C:14]([C:16]1[N:17]([CH3:23])[C:18](Br)=[N:19][C:20]=1[CH3:21])=[O:15])[CH3:12]>>[CH2:11]([O:13][C:14]([C:16]1[N:17]([CH3:23])[C:18]([C:10]#[C:9][C:3]2[C:2]([Cl:1])=[CH:7][CH:6]=[CH:5][C:4]=2[Cl:8])=[N:19][C:20]=1[CH3:21])=[O:15])[CH3:12]

参加物

反応物 2

HCID 13897513ethyl 2-bromo-1,4-dimethyl-1H-imidazole-5-carboxylate

HCID 22271730Benzene, 1,3-dichloro-2-ethynyl-

生成物 1

HCID 99457302-(2,6-Dichloro-phenylethynyl)-3,5-dimethyl-3H-imidazole-4-carboxylic acid ethyl ester

実験手順

The title compound, MS: m/e=197.4 (M+H+) was prepared in accordance with the general method of example 1b from 1,3-dichloro-2-ethynyl-benzene and 2-bromo-3,5-dimethyl-3H-imidazole-4-carboxylic acid ethyl ester.

出典と根拠

ORDレコード: ord-10165ae160ae40ec93690a7692d24e2b
出典データセット: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06706707B2

反応ノート

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