3-Methylphenylacetylene → 3,5-Dimethyl-2-m-tolylethynyl-3H-imidazole-4-carboxylic acid ethyl ester

反応式

[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH3:9])[CH:4]=1)#[CH:2].[CH2:10]([O:12][C:13]([C:15]1[N:16]([CH3:22])[C:17](Br)=[N:18][C:19]=1[CH3:20])=[O:14])[CH3:11]>>[CH2:10]([O:12][C:13]([C:15]1[N:16]([CH3:22])[C:17]([C:2]#[C:1][C:3]2[CH:4]=[C:5]([CH3:9])[CH:6]=[CH:7][CH:8]=2)=[N:18][C:19]=1[CH3:20])=[O:14])[CH3:11]

参加物

反応物 2

HCID 1366003-Methylphenylacetylene

HCID 13897513ethyl 2-bromo-1,4-dimethyl-1H-imidazole-5-carboxylate

生成物 1

HCID 99655763,5-Dimethyl-2-m-tolylethynyl-3H-imidazole-4-carboxylic acid ethyl ester

実験手順

The title compound, MS: m/e=283.6 (M+H+), was prepared in accordance with the general method of example 1b from 1-ethynyl-3-methyl-benzene and 2-bromo-3,5-dimethyl-3H-imidazole-4-carboxylic acid ethyl ester.

出典と根拠

ORDレコード: ord-13eb5773655d4e50838db3d487030975
出典データセット: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06706707B2

反応ノート

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