化工社化工社 化学情報印刷レポート · 研究参考用
Dehydroepiandrosterone → Dehydroepiandrosterone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dehydroepiandrosterone | HCID 5881 | — |
| 反応物 | 22,29-EPOXY-3,29-DIHYDROXY-14beta-STIGMASTAN-15-ONE | HCID 69625815 | — |
| 生成物 | Dehydroepiandrosterone | HCID 5881 | — |
| 生成物 | HCID 178420941 | HCID 178420941 | — |
反応手順
The synthesis of 22,29-epoxy-3,29-dihydroxy-14β-stigmastan-15-one (260) can be accomplished in ten steps from dehydroisoandrosterone (247). Catalytic hydrogenation of the Δ5 carbon-carbon double bond in compound 247 yields compound 250, which contains a trans-fused A/B ring-system. Compound 247 is dissolved in EtOAc and 10% Pd/C is added. The mixture is stirred under H2 at room temperature overnight. Filtration through celite and concentration yields compound 250, which can be used directly in the next reaction.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06706701B1 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-d863766c08014899a9c4dffcca1796e9 |
| 出典メモ | uspto-grants-2004_03 |