Potassium Carbonate → 3-Allyl-5-[(2-chloro-4-fluorophenoxy)methyl]-1,2,4-oxadiazole
反応式
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[OH:9].[CH2:10]([C:13]1[N:17]=[C:16]([CH2:18]Cl)[O:15][N:14]=1)[CH:11]=[CH2:12].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:10]([C:13]1[N:17]=[C:16]([CH2:18][O:9][C:3]2[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=2[Cl:1])[O:15][N:14]=1)[CH:11]=[CH2:12]参加物
5
実験手順
0.71 g of 2-chloro-4-fluorophenol, 0.77 g of 3-allyl-5-chloromethyl-1,2,4-oxadiazole and 0.83 of potassium carbonate were added to 20 ml of acetone. After completion of the reaction, the resulting precipitates were filtered out from the mixture and then acetone was removed by distillation, and the residue was purified by column chromatography (benzene:hexane=1:1) to obtain 1.05 g of the desired product(yield: 80.8%).
後処理
- customAfter completion of the reaction
- customthe resulting precipitates
- filtrationwere filtered out from the mixture
- customacetone was removed by distillation
- customthe residue was purified by column chromatography (benzene:hexane=1:1)
出典と根拠
- ORDレコード
- ord-78085214e0d5496ab614bdad6a715709
- 出典データセット
- uspto-grants-1993_09
- 特許番号
- US05242890
反応ノート
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