Potassium Carbonate → 3-Allyl-5-[(2-chloro-4-fluorophenoxy)methyl]-1,2,4-oxadiazole

HRID 4896

反応式

HRID 4896 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[OH:9].[CH2:10]([C:13]1[N:17]=[C:16]([CH2:18]Cl)[O:15][N:14]=1)[CH:11]=[CH2:12].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:10]([C:13]1[N:17]=[C:16]([CH2:18][O:9][C:3]2[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=2[Cl:1])[O:15][N:14]=1)[CH:11]=[CH2:12]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 748142-Chloro-4-fluorophenolHCID 197971305-(Chloromethyl)-3-(prop-2-en-1-yl)-1,2,4-oxadiazole

生成物 1

HCID 197971293-Allyl-5-[(2-chloro-4-fluorophenoxy)methyl]-1,2,4-oxadiazole収率 80.8%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

0.71 g of 2-chloro-4-fluorophenol, 0.77 g of 3-allyl-5-chloromethyl-1,2,4-oxadiazole and 0.83 of potassium carbonate were added to 20 ml of acetone. After completion of the reaction, the resulting precipitates were filtered out from the mixture and then acetone was removed by distillation, and the residue was purified by column chromatography (benzene:hexane=1:1) to obtain 1.05 g of the desired product(yield: 80.8%).

後処理

  1. customAfter completion of the reaction
  2. customthe resulting precipitates
  3. filtrationwere filtered out from the mixture
  4. customacetone was removed by distillation
  5. customthe residue was purified by column chromatography (benzene:hexane=1:1)

出典と根拠

ORDレコード
ord-78085214e0d5496ab614bdad6a715709
出典データセット
uspto-grants-1993_09
特許番号
US05242890

関連ノート

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