Ammonium Hydroxide → 5-Amino-6-fluoro-3-(3-methyl-2-pyridyl)-1,2-benzisothiazole
反応式
[NH2:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([S:9]C#N)=[C:4]([C:12](=O)[C:13]2[C:18]([CH3:19])=[CH:17][CH:16]=[CH:15][N:14]=2)[CH:3]=1.[OH-].[NH4+:22]>CO>[NH2:1][C:2]1[C:7]([F:8])=[CH:6][C:5]2[S:9][N:22]=[C:12]([C:13]3[C:18]([CH3:19])=[CH:17][CH:16]=[CH:15][N:14]=3)[C:4]=2[CH:3]=1参加物
4
実験手順
A mixture of 4-amino-5-fluoro-2-(3-methylpicolinoyl)phenyl thiocyanate(3.06 g, 0.0112 mole), concentrated ammonium hydroxide (300 ml) and methanol (300 ml) is stirred overnight at room temperature. The methanol is removed in vacuo and the resultant mixture is filtered to afford the title compound as a green solid (1.93 g, 66.6%) which is identified by NMR spectral analysis.
後処理
- customThe methanol is removed in vacuo
- filtrationthe resultant mixture is filtered
出典と根拠
- ORDレコード
- ord-315bbe081a5247e9bd79bf30d08c872f
- 出典データセット
- uspto-grants-2004_03
- 特許番号
- US06706663B2
反応ノート
読み込み中…