Tert-butyl 4-{3-[6-amino-5-chloro-2-(methyloxy)-3-pyridinyl]-3-oxopropyl}-1-piperidinecarboxylate → 1-(6-Amino-5-chloro-2-methoxy-3-pyridinyl)-3-(4-piperidinyl)-1-propanone hydrochloride

HRID 489794ノート

反応式

HRID 489794 の反応式
[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH3:9])[C:5]([C:10](=[O:26])[CH2:11][CH2:12][CH:13]2[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]2)=[CH:4][C:3]=1[Cl:27]>Cl>[ClH:27].[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH3:9])[C:5]([C:10](=[O:26])[CH2:11][CH2:12][CH:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)=[CH:4][C:3]=1[Cl:27]

参加物

3

反応物 1

HCID 22262604Tert-butyl 4-{3-[6-amino-5-chloro-2-(methyloxy)-3-pyridinyl]-3-oxopropyl}-1-piperidinecarboxylate

生成物 1

HCID 222625861-(6-Amino-5-chloro-2-methoxy-3-pyridinyl)-3-(4-piperidinyl)-1-propanone hydrochloride収率 94.6%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

A mixture of tert-butyl 4-{3-[6-amino-5-chloro-2-(methyloxy)-3-pyridinyl]-3-oxopropyl}-1-piperidinecarboxylate (step 5, 610 mg, 1.53 mmol) in 10% methanolic hydrochloric acid (6 ml) was stirred at room temperature for 18 h. The formed solid was collected by filtration, washed with methanol and dried to give 242.0 mg (47%) of the title compound as a white solid.

後処理

  1. filtrationThe formed solid was collected by filtration
  2. washwashed with methanol
  3. customdried

出典と根拠

ORDレコード
ord-509e1b17f1d84e4b9e43e102ff5e38d4
出典データセット
uspto-grants-2005_12
特許番号
US06979690B2

反応ノート

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