Methanimidamide, N,N-diphenyl- → 2-(3-Bromobenzoyl)-3-phenylaminoacrylonitrile

HRID 489825

反応式

HRID 489825 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][CH:12]=1)[C:5]([CH2:7][C:8]#[N:9])=[O:6].[C:13]1([N:19](C2C=CC=CC=2)[CH:20]=N)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C1(C)C(C)=CC=CC=1.CCOCC>[Br:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][CH:12]=1)[C:5]([C:7](=[CH:20][NH:19][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:8]#[N:9])=[O:6]

参加物

5

反応物 2

HCID 78296Methanimidamide, N,N-diphenyl-HCID 27568393-(3-Bromophenyl)-3-oxopropanenitrile

生成物 1

HCID 696866072-(3-Bromobenzoyl)-3-phenylaminoacrylonitrile収率 74.3%

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 7237O-Xylene溶媒

実験手順

A mixture of 2-(3-bromobenzoyl)acetonitrile (16.5 g, 73.6 mmol) and N,N-diphenylformamidine (14.5 g, 73.6 mmol) in xylene (100 ml) was heated at reflux under a nitrogen atmosphere. After 3 h, the reaction was cooled to room temperature and diluted with ether to give 2-(3-bromobenzoyl)-3-phenylaminoacrylonitrile (17.9 g) as a solid.

後処理

  1. temperaturewas heated
  2. temperatureat reflux under a nitrogen atmosphere

出典と根拠

ORDレコード
ord-fe2f1ba6930c43bf8c2b178662f06b5a
出典データセット
uspto-grants-2005_12
特許番号
US06979693B2

関連ノート

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