(4-Fluorophenyl)hydrazine → 5-Amino-1-(2,4-difluorophenyl)-4-(2-methylfuran-3-oyl)-pyrazole

HRID 489859

反応式

HRID 489859 の反応式
[CH3:1][C:2]1[O:3][CH:4]=[CH:5][C:6]=1[C:7]([CH2:9][C:10]#[N:11])=[O:8].F[C:13]1C=CC(NN)=CC=1.[F:21][C:22]1[CH:27]=[C:26]([F:28])[CH:25]=[CH:24][C:23]=1[NH:29][NH2:30]>>[NH2:11][C:10]1[N:29]([C:23]2[CH:24]=[CH:25][C:26]([F:28])=[CH:27][C:22]=2[F:21])[N:30]=[CH:13][C:9]=1[C:7]([C:6]1[CH:5]=[CH:4][O:3][C:2]=1[CH3:1])=[O:8]

参加物

4

反応物 3

HCID 69982(4-Fluorophenyl)hydrazineHCID 588958(2,4-Difluoro-phenyl)-hydrazineHCID 7367553-(2-Methyl-3-Furyl)-3-Oxopropanenitrile

生成物 1

HCID 222627575-Amino-1-(2,4-difluorophenyl)-4-(2-methylfuran-3-oyl)-pyrazole

実験手順

Proceeding as described in Example 1, step 2, but replacing 2-(3-bromobenzoyl)acetonitrile with 2-(2-methyl-3-furanoyl)acetonitrile and substituting 4-fluorophenylhydrazine in step 3 with 2,4-difluorophenylhydrazine was obtained 5-amino-1-(2,4-difluorophenyl)-4-(2-methylfuran-3-oyl)-pyrazole (116).

出典と根拠

ORDレコード
ord-f72e5f55fdab43fdb5bd7419b5839ae4
出典データセット
uspto-grants-2005_12
特許番号
US06979693B2

関連ノート

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