4,4'-Difluorobenzophenone → (4-Aminophenyl)(4-fluorophenyl)methanone

HRID 490015ノート

反応式

HRID 490015 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)([OH:11])C#C)=[CH:4][CH:3]=1.FC1C=CC(C(C2C=CC(F)=CC=2)=O)=CC=1>>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)=[O:11])=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 95824,4'-DifluorobenzophenoneHCID 876134721-(4-Aminophenyl)-1-(4-fluorophenyl)-2-propyn-1-ol

生成物 1

HCID 577826(4-Aminophenyl)(4-fluorophenyl)methanone

実験手順

Referring now to FIG. 2, wherein one non-limiting approach to the 1-(4-aminophenyl)-1-(4-fluorophenyl)-2-propyn-1-ol is presented, 4,4′-difluorobenzophenone (7) is reacted with a secondary amine HNR′″R″″ to give the 4-amino-4′-fluorobenzophenone 8, where R′″ and R″″ may be the same as R36 and R37, respectively, as set forth and claimed herein. Acetylide anion, for example, sodium acetylide in acetylene saturated dimethylformamide, is added to the carbonyl of 4-amino-4′-fluorobenzophenone 8 to give, upon aqueous workup, 1-(4-aminophenyl)-1-(4-fluorophenyl)-2-propyn-1-ol 9.

出典と根拠

ORDレコード
ord-bc6840b61a2f47df85eb97f708fd6de6
出典データセット
uspto-grants-2009_05
特許番号
US07527754B2

反応ノート

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